Baseline Corrected
Time (hr) N
Observed QTc (ms)
QTc (ms)
Mean 95% CI Mean 90% CI
0 mg 0.50 22 387.44 [380.42, 394.46] −8.28 [−10.64, −5.92]
1.00 22 390.26 [382.63, 397.89] −5.45 [−8.03, −2.87]
1.50 22 390.25 [382.93, 397.58] −5.46 [−7.94, −2.98]
2.00 22 393.33 [385.59, 401.07] −2.39 [−4.30, −0.48]
2.50 22 391.62 [383.70, 399.55] −4.09 [−7.65, −0.53]
3.00 22 389.84 [382.04, 397.63] −5.88 [−8.88, −2.87]
3.50 22 386.17 [379.34, 393.00] −9.55 [−12.91, −6.18]
4.00 21 387.96 [379.88, 396.05] −7.75 [−11.02, −4.49]
5.00 22 386.33 [378.26, 394.39] −9.39 [−13.03, −5.75]
6.00 22 388.23 [380.10, 396.36] −7.49 [−12.56, −2.41]
7.00 22 386.25 [378.39, 394.10] −9.47 [−14.16, −4.78]
8.00 22 386.21 [378.00, 394.43] −9.50 [−13.84, −5.16]
12.00 22 382.63 [375.14, 390.11] −13.09 [−16.89, −9.29]
14.00 22 383.57 [375.97, 391.17] −12.14 [−15.52, −8.76]
24.00 21 390.65 [382.80, 398.51] −5.08 [−9.10, −1.06]
120 mg 0.50 21 389.81 [381.86, 397.75] −5.74 [−8.04, −3.43]
1.00 21 395.33 [388.41, 402.24] −0.22 [−3.22, 2.78]
1.50 21 391.46 [383.93, 398.99] −4.08 [−7.19, −0.97]
2.00 21 397.11 [388.91, 405.30] 1.56 [−1.61, 4.74]
2.50 21 396.48 [388.14, 404.82] 0.94 [−2.91, 4.78]
3.00 21 393.05 [384.56, 401.54] −2.49 [−5.73, 0.74]
3.50 21 389.71 [381.09, 398.34] −5.83 [−9.61, −2.05]
4.00 21 391.77 [382.82, 400.73] −3.77 [−7.31, −0.23]
5.00 21 389.43 [381.54, 397.32] −6.11 [−10.43, −1.79]
6.00 21 390.59 [382.93, 398.25] −4.96 [−9.83, −0.08]
7.00 21 389.87 [382.58, 397.17] −5.67 [−10.29, −1.05]
8.00 21 388.67 [381.02, 396.32] −6.88 [−11.33, −2.42]
12.00 21 385.59 [377.98, 393.20] −9.96 [−14.28, −5.63]
14.00 21 387.03 [379.28, 394.78] −8.51 [−12.37, −4.65]
24.00 21 388.81 [381.93, 395.69] −6.74 [−10.48, −2.99]