Baseline Corrected
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---|---|---|---|---|---|---|
Time (hr) | N |
Observed QTc (ms)
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QTc (ms)
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Mean | 95% CI | Mean | 90% CI | |||
0 mg | 0.50 | 22 | 387.44 | [380.42, 394.46] | −8.28 | [−10.64, −5.92] |
1.00 | 22 | 390.26 | [382.63, 397.89] | −5.45 | [−8.03, −2.87] | |
1.50 | 22 | 390.25 | [382.93, 397.58] | −5.46 | [−7.94, −2.98] | |
2.00 | 22 | 393.33 | [385.59, 401.07] | −2.39 | [−4.30, −0.48] | |
2.50 | 22 | 391.62 | [383.70, 399.55] | −4.09 | [−7.65, −0.53] | |
3.00 | 22 | 389.84 | [382.04, 397.63] | −5.88 | [−8.88, −2.87] | |
3.50 | 22 | 386.17 | [379.34, 393.00] | −9.55 | [−12.91, −6.18] | |
4.00 | 21 | 387.96 | [379.88, 396.05] | −7.75 | [−11.02, −4.49] | |
5.00 | 22 | 386.33 | [378.26, 394.39] | −9.39 | [−13.03, −5.75] | |
6.00 | 22 | 388.23 | [380.10, 396.36] | −7.49 | [−12.56, −2.41] | |
7.00 | 22 | 386.25 | [378.39, 394.10] | −9.47 | [−14.16, −4.78] | |
8.00 | 22 | 386.21 | [378.00, 394.43] | −9.50 | [−13.84, −5.16] | |
12.00 | 22 | 382.63 | [375.14, 390.11] | −13.09 | [−16.89, −9.29] | |
14.00 | 22 | 383.57 | [375.97, 391.17] | −12.14 | [−15.52, −8.76] | |
24.00 | 21 | 390.65 | [382.80, 398.51] | −5.08 | [−9.10, −1.06] | |
120 mg | 0.50 | 21 | 389.81 | [381.86, 397.75] | −5.74 | [−8.04, −3.43] |
1.00 | 21 | 395.33 | [388.41, 402.24] | −0.22 | [−3.22, 2.78] | |
1.50 | 21 | 391.46 | [383.93, 398.99] | −4.08 | [−7.19, −0.97] | |
2.00 | 21 | 397.11 | [388.91, 405.30] | 1.56 | [−1.61, 4.74] | |
2.50 | 21 | 396.48 | [388.14, 404.82] | 0.94 | [−2.91, 4.78] | |
3.00 | 21 | 393.05 | [384.56, 401.54] | −2.49 | [−5.73, 0.74] | |
3.50 | 21 | 389.71 | [381.09, 398.34] | −5.83 | [−9.61, −2.05] | |
4.00 | 21 | 391.77 | [382.82, 400.73] | −3.77 | [−7.31, −0.23] | |
5.00 | 21 | 389.43 | [381.54, 397.32] | −6.11 | [−10.43, −1.79] | |
6.00 | 21 | 390.59 | [382.93, 398.25] | −4.96 | [−9.83, −0.08] | |
7.00 | 21 | 389.87 | [382.58, 397.17] | −5.67 | [−10.29, −1.05] | |
8.00 | 21 | 388.67 | [381.02, 396.32] | −6.88 | [−11.33, −2.42] | |
12.00 | 21 | 385.59 | [377.98, 393.20] | −9.96 | [−14.28, −5.63] | |
14.00 | 21 | 387.03 | [379.28, 394.78] | −8.51 | [−12.37, −4.65] | |
24.00 | 21 | 388.81 | [381.93, 395.69] | −6.74 | [−10.48, −2.99] |