preprocess

Description

Pre-processes data Computes QTcB, QTcF, deltaQTcF, deltaQTcB, deltaHR, deltaQTcB Baseline Mean, deltaQTcF Baseline Mean, deltaHR Baseline Mean

Usage

preprocess(
  data,
  qt_col = QT,
  qtbl_col = QTBL,
  rr_col = RR,
  rrbl_col = RRBL,
  hr_col = HR,
  hrbl_col = HRBL,
  qtcf_col = QTCF,
  qtcfbl_col = QTCFBL,
  qtcb_col = QTCB,
  qtcbbl_col = QTCBBL,
  id_col = ID,
  deduplicate = TRUE
)

Arguments

Name	Description
`data`	Data frame containing QTc data
`qt_col`	an unquoted column name of QT measurements, QT by default
`qtbl_col`	an unquoted column name of baseline QT measurements, QTBL by default
`rr_col`	an unquoted column name of RR measurements, RR by default
`rrbl_col`	an unquoted column name of baseline RR measurements, RRBL by default
`hr_col`	an unquoted column name of HR measurements, HR by default
`hrbl_col`	an unquoted column name of baseline HR measurements, HRBL by default
`qtcf_col`	an unquoted column name of QTCF measurements, QTCF by default
`qtcfbl_col`	an unquoted column name of baseline QTCF measurements, QTCFBL by default
`qtcb_col`	an unquoted column name of QTCB measurements, QTCB by default
`qtcbbl_col`	an unquoted column name of baseline QTCB measurements, QTCBBL by default
`id_col`	an unquoted column name of ID data
`deduplicate`	boolean, whether baseline values are duplicated over rows. If true duplicates will be removed from average

Returns

dataframe with deltas computed from BL

Examples

preprocess(data)

# A tibble: 643 × 30
      ID TRTG   DOSE DOSEU DOSEF  NTLD TAFD   CONC CONCU    RR    HR    QT  RRBL
   <dbl> <fct> <dbl> <chr> <fct> <dbl> <chr> <dbl> <chr> <dbl> <dbl> <dbl> <dbl>
 1  1001 Plac…     0 mg    0 mg    0.5 0.5 …     0 <NA>   968   62.0  381.  851
 2  1002 Plac…     0 mg    0 mg    0.5 0.5 …     0 <NA>  1097.  54.7  405. 1193.
 3  1003 Plac…     0 mg    0 mg    0.5 0.5 …     0 <NA>  1026.  58.5  394.  923.
 4  1004 Plac…     0 mg    0 mg    0.5 0.5 …     0 <NA>   862.  69.6  396.  883.
 5  1005 Plac…     0 mg    0 mg    0.5 0.5 …     0 <NA>  1060.  56.6  398  1126.
 6  1006 Plac…     0 mg    0 mg    0.5 0.5 …     0 <NA>   998   60.2  385   999
 7  1007 Plac…     0 mg    0 mg    0.5 0.5 …     0 <NA>   919.  65.4  399.  909
 8  1008 Plac…     0 mg    0 mg    0.5 0.5 …     0 <NA>   827.  72.5  371   991
 9  1009 Plac…     0 mg    0 mg    0.5 0.5 …     0 <NA>   872.  68.9  368.  798.
10  1010 Plac…     0 mg    0 mg    0.5 0.5 …     0 <NA>  1070.  56.1  424. 1071
# ℹ 633 more rows
# ℹ 17 more variables: HRBL <dbl>, QTBL <dbl>, QTCB <dbl>, QTCF <dbl>,
#   QTCBBL <dbl>, QTCFBL <dbl>, HRBLM <dbl>, deltaHRBL <dbl>, QTCBBLM <dbl>,
#   deltaQTCBBL <dbl>, QTCFBLM <dbl>, deltaQTCFBL <dbl>, deltaQTCB <dbl>,
#   deltaQTCF <dbl>, deltaRR <dbl>, deltaHR <dbl>, deltaQT <dbl>