compute_potential_hysteresis

Description

Detects the pressence of hysteresis

Usage

compute_potential_hysteresis(
  data,
  ntime_col,
  deltaqtc_col,
  conc_col,
  group_col
)

Arguments

Name	Description
data	a dataframe of QTc dataset
ntime_col	an unquoted column name for nominal timepoints
deltaqtc_col	an unquoted column name of dQTC measurements
conc_col	an unquoted column name of concentration measurements
group_col	an unquoted column name of grouping column - usually DOSEF

Returns

a bool of TRUE if hysteresis detected else FALSE

Examples

data <- preprocess(data)
 data <- dplyr::filter(data, DOSE == 120)

 compute_potential_hysteresis(
   data,
   NTLD,
   deltaQTCF,
   CONC,
   DOSEF)

compute_potential_hysteresis.R

[1] FALSE

Criteria for hysteresis

1. At least three time points that have $\Delta$QTc greater than 5 ms
2. $\lvert T_{\text{max}} - U_{\text{max}} \rvert \geq 1 \text{ hr}$, where $T_{\text{max}}$ is time of maximal concentration, and $U_{\text{max}}$ is time of maximal $\Delta$QTc