compute_pk_parameters

Description

Generates pk parameters Cmax and Tmax for exporsure predictions.

Usage

compute_pk_parameters(
  data,
  id_col,
  dose_col,
  conc_col,
  ntime_col,
  group_col = NULL
)

Arguments

Name	Description
data	a dataframe of QTc dataset
id_col	an unquoted column name of ID
dose_col	an unquoted column name of Dose
conc_col	an unquoted column name of Concentration measurements
ntime_col	an unquoted column name nominal times
group_col	an unquoted column name of additional grouping column

Returns

a dataframe of pk parameters

Examples

compute_pk_parameters(
   preprocess(data) %>% dplyr::filter(DOSE != 0),
   ID,
   DOSE,
   CONC,
   NTLD)

compute_pk_parameters.R

# A tibble: 1 × 10
  group     N Tmax_median Tmax_max Tmax_min Cmax_gm Cmax_cv Cmax_median Cmax_max
  <dbl> <int>       <dbl>    <dbl>    <dbl>   <dbl>   <dbl>       <dbl>    <dbl>
1   120    21           1        2      0.5    114.    57.0         102      368
# ℹ 1 more variable: Cmax_min <dbl>