compute_enGRI

This function comes from:

Ferber, G., Darpo, B., Garnett, C. et al. Detection and impact of hysteresis when evaluating a drug’s QTc effect using concentration-QTc analysis. J Pharmacokinet Pharmacodyn 48, 187–202 (2021). https://doi.org/10.1007/s10928-020-09725-w

Description

Exposure Normalized GRI computation

Usage

compute_enGRI(
  data,
  conc_gm_col,
  ddqtc_col
)

Arguments

Name	Description
`data`	a dataframe of QTc dataset
`conc_gm_col`	CONC geometric mean column name
`ddqtc_col`	delta delta QTc column name

Returns

a numeric (ms) of enGRI score

Examples

compute_enGRI(preprocess(data), CONC, deltaQTCF)

[1] 11.56442