compute_ecg_param_summary

Description

Generates a tibble of summary of QTc, dQTc and ddQTc over time stratified by dose

Usage

compute_ecg_param_summary(
  data,
  ntime_col,
  dose_col,
  ecg_param_col,
  deltaecg_param_col,
  group_col = NULL,
  reference_dose = NULL,
  conf_int = 0.95
)

Arguments

Name	Description
`data`	a dataframe containing QTc dataset
`ntime_col`	an unquoted column name for nominal time data
`dose_col`	an unquoted column name for dose data
`ecg_param_col`	an unquoted column name for QTc measurements
`deltaecg_param_col`	an unquoted column name for deltaQTc measurements
`group_col`	an unquoted column name for additional grouping column
`reference_dose`	an optional argument for specifying reference dose for delta delta QTc computation
`conf_int`	an optional argument for setting confidence interval. default 0.95

Returns

a tibble of QTc/deltaQTc/delta delta QTc summary over dose and time.

Examples

data <- data %>% preprocess()

 compute_ecg_param_summary(data, NTLD, DOSEF, QTCF, deltaQTCF)

# A tibble: 30 × 10
   dose   time     n mean_ecg ecg_low ecg_high group mean_decg decg_low
   <fct> <dbl> <int>    <dbl>   <dbl>    <dbl> <chr>     <dbl>    <dbl>
 1 0 mg    0.5    22     387.    380.     394. 0 mg      -8.28   -11.1
 2 0 mg    1      22     390.    383.     398. 0 mg      -5.45    -8.57
 3 0 mg    1.5    22     390.    383.     398. 0 mg      -5.46    -8.46
 4 0 mg    2      22     393.    386.     401. 0 mg      -2.39    -4.70
 5 0 mg    2.5    22     392.    384.     400. 0 mg      -4.09    -8.40
 6 0 mg    3      22     390.    382.     398. 0 mg      -5.88    -9.51
 7 0 mg    3.5    22     386.    379.     393. 0 mg      -9.55   -13.6
 8 0 mg    4      21     388.    380.     396. 0 mg      -7.75   -11.7
 9 0 mg    5      22     386.    378.     394. 0 mg      -9.39   -13.8
10 0 mg    6      22     388.    380.     396. 0 mg      -7.49   -13.6
# ℹ 20 more rows
# ℹ 1 more variable: decg_high <dbl>