compute_contrast_observations

Description

Compute contrast observations for prediction plots

Usage

compute_contrast_observations(
  data,
  conc_col,
  dv_col,
  id_col = NULL,
  ntime_col = NULL,
  trt_col = NULL,
  treatment_predictors,
  control_predictors = NULL,
  contrast_method = c(
  "matched",
  "group"
)
)

Arguments

Name	Description
`data`	a dataframe of QTc dataset
`conc_col`	an unquoted column name of drug concentration measurements
`dv_col`	an unquoted column name of dQTC measurements
`id_col`	an unquoted column name of ID data, used when control predictors is provided to compute delta delta dv
`ntime_col`	an unquoted column name of Nominal time data, used when control predictors is provided to compute delta delta dv
`trt_col`	an unquoted column name of Treatment group data, used when control predictors is provided to compute delta delta dv
`treatment_predictors`	a list for predictions with model. Should contain a value for each predictor in the model.
`control_predictors`	an optional list for contrast predictions
`contrast_method`	a string specifying contrast method: “matched” for individual ID+time matching (crossover studies), “group” for group-wise subtraction (parallel studies)

Returns

a tibble with columns: group, conc, dv

Examples

data <- preprocess(data)

 # Simple case: no control group
 obs_data <- compute_contrast_observations(
   data,
   CONC,
   deltaQTCF,
   treatment_predictors = list(TRTG = "Verapamil HCL")
 )
 obs_data

 # Matched contrast (crossover study)
 contrast_data <- compute_contrast_observations(
   data,
   CONC,
   deltaQTCF,
   ID,
   NTLD,
   TRTG,
   treatment_predictors = list(TRTG = "Verapamil HCL"),
   control_predictors = list(TRTG = "Placebo"),
   contrast_method = "matched"
 )
 contrast_data

# A tibble: 643 × 3
   group         conc     dv
   <chr>        <dbl>  <dbl>
 1 Observations     0  -6.01
 2 Observations     0 -12.0
 3 Observations     0  -5.45
 4 Observations     0 -22.5
 5 Observations     0   1.29
 6 Observations     0  -6.54
 7 Observations     0 -12.5
 8 Observations     0 -11.0
 9 Observations     0  -7.72
10 Observations     0  -2.76
# ℹ 633 more rows
# A tibble: 313 × 3
   group         conc      dv
   <chr>        <dbl>   <dbl>
 1 Observations 180     1.57
 2 Observations  51.5   4.52
 3 Observations  46.1   6.96
 4 Observations 251    11.0
 5 Observations  72.6 -10.5
 6 Observations 201     1.58
 7 Observations  91.1  -3.82
 8 Observations  50     1.46
 9 Observations 368     8.09
10 Observations  37.8  -0.864
# ℹ 303 more rows